Lieven Gentaur
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A New Perspective on Infectious Disease Surveillance
Beyond the single pathogen
Many infections involve polymicrobial communities where commensals, opportunistic organisms, and primary pathogens interact. Profiling helps reveal these hidden interactions.
Early outbreak detection
Shifts in microbial composition can serve as early warning signals for emerging infections, antimicrobial resistance, or nosocomial outbreaks.
Tracking transmission dynamics
By comparing microbial community signatures across patients, hospitals, or regions, researchers can map the spread of infectious agents with higher resolution.
Innovative Applications
Antimicrobial Resistance (AMR) Surveillance
Microbial community profiling identifies resistance genes across microbial populations, supporting more informed antimicrobial stewardship strategies.
Host Microbiome Pathogen Interactions
Profiling helps uncover how commensal microbiota modulate immune responses and either protect against or exacerbate infections.
Environmental and Hospital Surveillance
Air, water, and surface microbiome monitoring provides data on potential reservoirs and transmission pathways of infectious agents..
Personalized Medicine
Microbial signatures could guide individualized treatment plans by predicting infection severity, drug response, or risk of complications.